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Updated: Sep 13, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Massive perinatal hepatic necrosis from maternal oxytocin overdose

W H Robichaux1, J A Perper, A S Knisely

  • 1Department of Pathology, Children's Hospital of Pittsburgh, Pennsylvania.

Pediatric Pathology
|September 1, 1992
PubMed

Review of clinical records regarding administration of oxytocin may provide clues to the etiology of hepatic infarction in the neonate. The authors present a case in which a large and rapid maternal overdose of oxytocin (17,300 mU over 20 min) during end-stage labor was associated with neonatal death and extensive hepatic infarction. These findings represent novel complications of oxytocin administration.

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