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Updated: Sep 1, 2026

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
Published on: December 2, 2012
Virus meningo-encephalitis in Slovenia
Abstract:
The authors describe the main epidemiological features of the meningo-encephalitis observed in Slovenia since 1946. It is endemic there with occasional epidemic outbreaks; close study has been made of the epidemic which occurred in 1953. The disease is markedly seasonal, 95% of all cases in 1953 occurring from May to September. Another characteristic feature is the mention of tick bites in a very large number of case-histories; although the Slovenian tick fauna has not yet been systematically investigated, the generally incriminated vector is the tick Ixodes ricinus. In close association with this feature, the disease appears primarily among persons whose work lies in the woods where the ticks are found. This consequently affects the age distribution of patients, 56.2% of whom in 1953 were 11-30 years old. No spread of infection from person to person has been noted.The disease closely resembles the tick encephalitis observed in Czechoslovakia and the meningo-encephalitis described in western Russia and Austria. The authors consider it probable that the virus circulates in enzootic foci between rodents and ticks and that man is accidentally infected.
Insights
Meningo-encephalitis in Slovenia is a seasonal tick-borne disease, primarily affecting young adults working outdoors. The virus likely circulates between rodents and ticks, with humans being accidentally infected.
Area of Science:
- Epidemiology
- Virology
- Public Health
Background:
- Meningo-encephalitis has been observed in Slovenia since 1946, presenting endemic patterns with occasional epidemic outbreaks.
- A significant epidemic occurred in 1953, prompting detailed epidemiological investigation.
Purpose of the Study:
- To describe the main epidemiological features of meningo-encephalitis in Slovenia.
- To investigate the characteristics of the 1953 epidemic, including seasonality, transmission vectors, and affected demographics.
Main Methods:
- Retrospective epidemiological analysis of meningo-encephalitis cases in Slovenia since 1946.
- Focus on detailed study of the 1953 epidemic, including case histories and environmental associations.
Main Results:
- The disease exhibits marked seasonality, with 95% of 1953 cases occurring between May and September.
- Tick bites were reported in a large number of cases, implicating Ixodes ricinus as the probable vector.
- The disease predominantly affected individuals aged 11-30 (56.2% in 1953), often those working in tick-prevalent environments.
- No person-to-person transmission was observed.
Conclusions:
- Meningo-encephalitis in Slovenia shares characteristics with tick-borne encephalitis in neighboring countries.
- The virus is likely maintained in enzootic foci involving rodents and ticks.
- Human infection is presumed to be accidental, resulting from exposure to infected ticks.
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