Related Experiment Videos
[Synthesis and pharmacology of structural analogs of tienilic acids]
G de Saqui-Sannes1, G Baziard-Mouysset, M Payard
1Département de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
Pharmaceutica Acta Helvetiae
|January 1, 1992
Abstract:
Three structural analogs of tienilic acid were synthetized and evaluated for their diuretic activity in the rat. Two compounds are alpha substituted tienilic acid derivatives by an alkylated group. The third one is a conformationally restricted derivative through a cyclization process. All compounds fall to increase the urinary flow in the pharmacological assay.