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Plasma cholinesterase isozymes and REM latency in schizophrenia
M S Keshavan1, S P Mahadik, C F Reynolds
1Dept. of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
Psychiatry Research
|July 1, 1992
Abstract:
The relation between electroencephalographic sleep parameters and plasma cholinesterase isozymes was examined in a group of 19 unmedicated schizophrenic patients. Rapid eye movement (REM) latency was found to be significantly inversely correlated with isozyme 3 (mainly acetylcholinesterase). The results are discussed in relation to cholinergic involvement in the regulation of REM sleep and in the pathophysiology of schizophrenia.