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Related Experiment Videos

[Isosorbide 5-mononitrate (delayed release) in stable effort angina].

L Almenar Bonet1, V Miró Palau, J V Gimeno Gascón

  • 1Servicio de Cardiología, Hospital La Fe, Valencia.

Revista Espanola De Cardiologia
|August 1, 1992
PubMed
Summary

Sustained-release Isosorbide-5-Mononitrate (50 mg) effectively improved exercise tolerance and delayed angina onset in stable effort angina patients over 100 days. This treatment demonstrated significant benefits compared to placebo.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Stable effort angina significantly impacts patients' quality of life.
  • Current treatments aim to improve exercise tolerance and reduce angina episodes.

Purpose of the Study:

  • To evaluate the efficacy, tolerance, and hemodynamic effects of sustained-release Isosorbide-5-Mononitrate (50 mg) once daily.
  • To assess the drug's impact on exercise capacity and angina onset in patients with stable effort angina.

Main Methods:

  • A double-blind, randomized, crossover, placebo-controlled study.
  • Inclusion of 10 patients with stable effort angina confirmed by positive exercise tests.
  • Cycloergometry performed at baseline and at 4, 12, and 24 hours post-dose on days 1, 25, and 100.

Main Results:

Related Experiment Videos

  • Significant increase in time to 1 mm ST-segment depression at 4 and 12 hours post-dose (p < 0.05).
  • Considerable lengthening of time to angina onset at 4 and 12 hours post-dose (p < 0.05).
  • Significantly greater exercise duration at 4 and 12 hours post-dose compared to placebo (p < 0.05).

Conclusions:

  • Sustained-release Isosorbide-5-Mononitrate (50 mg) is effective in improving exercise tolerance and delaying angina in stable effort angina.
  • The observed benefits were consistent over 100 days of treatment.
  • The drug demonstrated good tolerance and favorable hemodynamic repercussions.