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Adhesion molecules in antibacterial defenses: effects of bacterial extracts

A Marchant1, J Duchow, M Goldman

  • 1Department of Immunology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.

Respiration; International Review of Thoracic Diseases
|January 1, 1992
PubMed

Insights

Bacterial extracts OM-85 BV and OM-89 boost the expression of adhesion molecules on polymorphonuclear leukocytes (PMN). This upregulation may explain how these extracts help prevent respiratory tract infections.

Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Polymorphonuclear leukocytes (PMN) adhere to vascular endothelium as an initial step in combating bacterial infections.
  • Adhesion molecules mediate PMN adherence and extravasation into infected tissues.

Purpose of the Study:

  • To investigate the effect of bacterial extracts OM-85 BV and OM-89 on PMN adhesion molecule expression.
  • To explore the potential link between enhanced adhesion molecule expression and the preventative effects of these extracts on respiratory infections.

Main Methods:

  • Treatment of PMNs with bacterial extracts OM-85 BV and OM-89.
  • Assessment of adhesion molecule expression on the surface of PMNs.

Main Results:

  • Bacterial extracts OM-85 BV and OM-89 significantly increase the expression of adhesion molecules on PMNs.
  • The upregulation of adhesion molecules suggests a mechanism for the beneficial effects of these bacterial extracts.

Conclusions:

  • Bacterial extracts OM-85 BV and OM-89 enhance PMN adhesion molecule expression.
  • This enhancement may contribute to the efficacy of these extracts in preventing respiratory tract infections.

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