Related Experiment Video
Updated: Aug 11, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
[Frequency and risk factors associated with metronidazole therapeutic noncompliance]
J Garduño-Espinosa1, M C Martínez-García, A Fajardo-Gutiérrez
1Unidad de Investigación Clínica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, Instituto Mexicano del Seguro Social, D.F.
Objective:
to determine the frequency and risk factors of non-compliance to oral metronidazole.
Study Design:
comparative cross-sectional survey.
Study Units:
111 patients who received oral metronidazole. SETTING CHARACTERISTICS: two medical units: one primary level unit and one secondary care unit of the Mexican Institute of Social Security.
Measurements:
non-compliance was assessed by home interview and pill count.
Main Results:
frequency of non-compliance was 55%. Risk factors for non-compliance were: female sex (OR = 3.0; p less than 0.05); side effects (OR = 3.1; p less than 0.05); low literacy (OR = 3.75; p less than 0.05). Stratified analysis showed no interaction between variables.
Conclusions:
frequency of non-compliance to metronidazole is high, and could affect the effectiveness of medical care. Female patients with low literacy and who suffer side effects are a high risk group for non-compliance.
More Related Videos
Related Concept Videos
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Factors Influencing Drug Absorption: Disease States and Pharmacology
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Therapeutic Drug Monitoring: Affecting Factors
Drug Toxicity: Risk factors
Inhibitors of Bacterial DNA Synthesis
Clinical Significance of Antibiotic Resistance

