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Is the irritable gut an inflamed gut?
1Intestinal Diseases Research Unit, McMaster University Medical Center, Hamilton, Ontario, Canada.
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1992
Summary
Neuroimmunology research shows the immune system influences psychological stress responses. This suggests the immune system may play a role in irritable bowel syndrome (IBS) pathogenesis.
Area of Science:
- Neuroimmunology
- Psychosomatic Medicine
- Gastroenterology
Background:
- Neuroimmunology has demonstrated immune system modulation of psychological stress responses.
- Irritable Bowel Syndrome (IBS) is a complex gastrointestinal disorder with varied clinical presentations and potential causes.
- Factors implicated in IBS include stress, diet, food intolerance, and infection.
Purpose of the Study:
- To explore the potential role of the immune system in the pathogenesis and pathophysiology of Irritable Bowel Syndrome (IBS).
Main Methods:
- Review of recent advances in neuroimmunology.
- Examination of evidence linking immune cells and gut function in IBS patients.
- Analysis of literature on immune system modulation of the gut motor system.
Main Results:
- Evidence suggests an increase in gut inflammatory cells in some IBS patients.
- Emerging literature indicates immunomodulation of the gut's motor system.
- Neuroimmunological findings support the immune system's involvement in stress responses.
Conclusions:
- The immune system may be implicated in the pathogenesis and pathophysiology of a subset of IBS patients.
- Further research is warranted to elucidate the precise role of neuroimmunological mechanisms in IBS.