Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The nuclear membrane.

C Dingwall¹, R Laskey

¹Wellcome/CRC Institute, Cambridge, United Kingdom.

Science (New York, N.Y.)

|November 6, 1992

Summary

The nuclear membrane regulates cellular functions, with ongoing research into its pore complex and associated signal transduction. Heat shock cognate protein Hsc70 may play a key role in nuclear protein import.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chronic hydrocephalus-induced hypoxia: increased expression of VEGFR-2+ and blood vessel density in hippocampus.

Neuroscience·2008

Same author

A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimer's disease.

Biochemical Society transactions·2007

Same author

Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

The Journal of clinical investigation·2001

Same author

The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly.

Molecular cell·2001

Same author

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts.

Current biology : CB·2001

Same author

Aggressive versus moderate lipid-lowering therapy in postmenopausal women with hypercholesterolemia: Rationale and design of the Beyond Endorsed Lipid Lowering with EBT Scanning (BELLES) trial.

American heart journal·2001

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

The nuclear membrane is a critical cellular barrier differentiating eukaryotic and prokaryotic cells.
It regulates transport and cellular processes, with the nuclear pore complex (NPC) being a key structure.
Signal transduction pathways interacting with the nucleus are increasingly recognized.

Purpose of the Study:

To review the dynamics and functions of the nuclear membrane and its associated structures.
To highlight remaining questions regarding nuclear pore complex transport.
To explore the role of signal transduction in nuclear functions and protein import.

Main Methods:

Literature review of studies on nuclear membrane dynamics, NPC function, and signal transduction.
Analysis of research on heat shock cognate protein Hsc70 (Hsc70) involvement in nuclear import.

Main Results:

The nuclear membrane provides unique regulatory capabilities not present in prokaryotes.
While NPC transport is extensively studied, many questions persist.
Evidence suggests signal transduction components associate with the nucleus, influencing its functions.

Conclusions:

The nuclear membrane's complex structure and function are vital for eukaryotic cells.
Further investigation into NPC transport mechanisms is warranted.
Heat shock cognate protein Hsc70 is proposed to have a specific signal-presentation role in nuclear protein import.

Related Experiment Videos