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B cells turn off virgin but not memory T cells.
1Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892.
Science (New York, N.Y.)
|November 13, 1992
Summary
T cell differentiation state dictates immune response outcomes. Virgin T cells tolerate B cell antigens, while experienced T cells activate, impacting tolerance and transplant survival.
Area of Science:
- Immunology
- Cellular Biology
Background:
- T cells have three responses to antigen recognition: no signal, activation, or inactivation.
- T cell differentiation state is crucial for determining the immune response outcome.
Purpose of the Study:
- To investigate how T cell differentiation affects responses to antigens presented by different antigen-presenting cells.
- To explore the implications of these findings for various tolerance phenomena and allograft survival.
Main Methods:
- Comparative analysis of virgin and experienced T cell responses.
- Antigen presentation assays using dendritic cells and B cells.
Main Results:
- Both virgin and experienced T cells activate upon antigen presentation by dendritic cells.
- Experienced T cells activate in response to B cell antigen presentation, whereas virgin T cells become tolerant.
Conclusions:
- T cell differentiation state critically influences immune responses to self and foreign antigens.
- Differential T cell responses to B cell-presented antigens may explain low-zone tolerance and transfusion effects on allografts.
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