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Antivenom and biological effects of ar-turmerone isolated from Curcuma longa (Zingiberaceae)
L A Ferreira1, O B Henriques, A A Andreoni
1Departamento de Bioquimica, Instituto Butantan, São Paulo, Brazil.
Abstract:
A potent antivenom against snakebite was isolated from Curcuma longa, a plant commonly used in traditional Brazilian medicine. The fraction consisting of ar-turmerone neutralized both the hemorrhagic activity present in Bothrops jararaca venom, and the lethal effect of Crotalus durissus terrificus venom in mice. Immunological studies demonstrated that this fraction also inhibited the proliferation and the natural killer activity of human lymphocytes.