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IgM-producing renal plasmacytoma.

T Kanoh1, K Yago, H Iwata

  • 1Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

Urology
|November 1, 1992
PubMed
Summary
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This case report details a rare instance of IgM-producing renal plasmacytoma, a kidney mass composed of plasma cells, in an elderly woman. Despite no bone lesions, the tumor rapidly progressed, highlighting the aggressive nature of this unusual presentation.

Area of Science:

  • Nephrology
  • Oncology
  • Immunology

Background:

  • Plasmacytoma, a plasma cell neoplasm, typically affects bone but can occur in extramedullary sites.
  • Renal involvement by plasmacytoma is uncommon, with limited documented cases.

Observation:

  • A seventy-six-year-old female presented with a renal mass identified as plasmacytoma.
  • Bone surveys were negative for lytic lesions, and Gallium-67 scans showed avid uptake in the renal mass.
  • Histologic examination revealed immature plasma cells producing IgM-lambda and amorphous deposits within the kidney.

Findings:

  • The renal parenchyma was destroyed by neoplastic plasma cells and associated proteinaceous deposits.
  • Immunofluorescence confirmed the presence of IgM-lambda, indicating the specific immunoglobulin produced by the plasma cells.

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  • This represents a unique case of a well-documented, IgM-producing renal plasmacytoma.

    • Implications:

    • This case expands the understanding of extramedullary plasmacytoma presentations.
    • Highlights the importance of considering rare renal masses in the differential diagnosis of kidney tumors.
    • Suggests that renal plasmacytomas, even without bone involvement, can be aggressive and rapidly progressive.