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Repeat plateletpheresis: the effects on the donor and the yield
G Rock1, P Tittley, M Sternbach
1Department of Medicine, University of Ottawa, Canada.
Vox Sanguinis
|January 1, 1992
Summary
Repeat plateletpheresis, a method for collecting platelets, temporarily lowers donor platelet counts and product yield. Donor hematological indices and lymphocyte counts showed transient changes, indicating a basic homeostatic mechanism.
Area of Science:
- Transfusion Medicine
- Hematology
Background:
- Single-donor platelets are crucial for HLA-matched transfusions, often necessitating repeat apheresis procedures.
- Donor safety guidelines vary regarding the frequency of platelet donation.
Purpose of the Study:
- To evaluate the hematological effects and product yields in donors undergoing frequent plateletpheresis.
Main Methods:
- 13 healthy donors underwent plateletpheresis every other day for 22 days (10 donations each).
- Hematological indices, platelet counts, and platelet yields were monitored throughout the study.
Main Results:
- Platelet counts decreased, reaching lowest values by the third donation, but recovered partially by the sixth.
- Platelet product yield initially decreased but subsequently increased.
- White blood cell counts remained stable, with a transient increase in lymphocytes observed.
Conclusions:
- Frequent plateletpheresis leads to temporary reductions in platelet count and yield.
- Donor hematological parameters demonstrate a homeostatic response to repeated apheresis.
- Further research is needed to fully understand the long-term implications of frequent platelet donation.