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Updated: Aug 22, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

[A structural analysis of hemato-encephalic barrier function in bacterial meningoencephalitis]

O A Iarosh

    Likars'Ka Sprava
    |February 1, 1992
    PubMed

    Insights

    In bacterial meningoencephalitis, increased metal content in cerebrospinal fluid correlates with weakened brain barrier function. Structural changes in microvessel walls underlie these barrier-transport disorders.

    Area of Science:

    • Neuroscience
    • Pathology
    • Biochemistry

    Context:

    • Bacterial meningoencephalitis presents a significant challenge in neurological disease.
    • Understanding the role of metal ions and blood-brain barrier integrity is crucial.

    Purpose:

    • To investigate the correlation between metal content in cerebrospinal fluid and blood-brain barrier function in bacterial meningoencephalitis.
    • To identify the structural basis of barrier dysfunction using scanning electron microscopy.

    Summary:

    • Correlation analysis revealed that elevated levels of macro- and microelements in cerebrospinal fluid are associated with reduced regulatory activity of barrier structures in patients with bacterial meningoencephalitis.
    • Pathomorphological examination via scanning electron microscopy identified structural alterations in microvessel walls, contributing to impaired barrier-transport functions.

    Impact:

    • This study elucidates the relationship between metal ion dysregulation and blood-brain barrier compromise in bacterial meningoencephalitis.
    • Findings highlight potential targets for therapeutic interventions aimed at restoring barrier integrity.

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