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Effects of the multiple risk factor intervention trial smoking cessation program on pulmonary function. A randomized
W S Browner1, A G Du Chene, S B Hulley
1Department of Epidemiology and Biostatistics, University of California, School of Medicine, San Francisco.
The Western Journal of Medicine
|November 1, 1992
Summary
Stop-smoking interventions may benefit heavy smokers
Area of Science:
- Pulmonary Medicine
- Clinical Trials
Background:
- Smoking is a major cause of pulmonary function decline.
- Previous studies suggest smoking cessation benefits lung function.
Purpose of the Study:
- To evaluate if a stop-smoking intervention modifies pulmonary function decline in smokers.
- To assess the impact of an intensive smoking cessation program.
Main Methods:
- Randomized controlled trial (Multiple Risk Factor Intervention Trial).
- 6,347 middle-aged male smokers with serial pulmonary function measurements (FEV1) over 6-7 years.
- Comparison between an intensive intervention group and a usual care group.
Main Results:
- No overall difference in FEV1 decline between groups.
- Beta-blocker use, more common in the intervention group, negatively impacted FEV1.
- Among non-beta-blocker users, heavy smokers in the intervention group showed slower FEV1 decline (11 ml/year) and higher final FEV1 (+90 ml).
Conclusions:
- Smoking cessation appears to have a beneficial effect on pulmonary function in heavy smokers.
- The study supports observational findings on the positive impact of quitting smoking on lung health.