Related Experiment Videos
Serine derivative with antitumor activity
Science (New York, N.Y.)
|March 4, 1960
Summary
The sodium salt of N-dichloroacetyl-DL-serine effectively inhibits sarcoma-37 tumor growth in mice, leading to complete tumor regression. This compound demonstrates a favorable safety profile, showing no toxicity or adverse effects in treated animals.
Area of Science:
- Oncology
- Pharmacology
- Biochemistry
Background:
- Sarcoma-37 is a murine tumor model.
- N-dichloroacetyl-DL-serine is a synthetic compound with potential therapeutic properties.
Purpose of the Study:
- To evaluate the efficacy of the sodium salt of N-dichloroacetyl-DL-serine against sarcoma-37.
- To assess the toxicity and physiological impact of the compound in mice.
Main Methods:
- Administration of the sodium salt of N-dichloroacetyl-DL-serine to mice bearing sarcoma-37.
- Monitoring tumor growth and regression.
- Assessing animal body weight, blood counts, and hemoglobin levels.
Main Results:
- The compound significantly depressed sarcoma-37 growth, resulting in complete tumor regression.
- No toxicity was observed at doses up to 4 gm/kg.
- Animals maintained body weight and showed normal blood parameters.
Conclusions:
- The sodium salt of N-dichloroacetyl-DL-serine is a potent and non-toxic agent against sarcoma-37.
- This compound shows promise as a potential anti-cancer therapeutic.