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A single vaccination with an inactivated hepatitis A liposome vaccine induces protective antibodies after only two
M Just1, R Berger, H Dreschsler
1University Children's Hospital, Basel, Switzerland.
Vaccine
|January 1, 1992
Abstract:
In the near future an inactivated hepatitis A vaccine will be commercially available. The recommended vaccination schedule will include at least two vaccinations 1 month apart. Giving two doses of vaccine on the same day in one injection results in protection after 2-4 weeks dependent on the adjuvant used. Hepatitis A virus incorporated into liposomes proved to be a suitable formulation in term of rapid seroconversion, high level of mean antibody content and low reactogenicity.