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[Dissolution rate and bioavailability of famotidine tablets]
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1992
Summary
This study assessed famotidine tablet dissolution and bioavailability in healthy volunteers. Famotidine tablets showed rapid dissolution and favorable pharmacokinetic parameters, indicating good drug absorption.
Area of Science:
- Pharmacology
- Pharmaceutical Sciences
- Analytical Chemistry
Context:
- Dissolution testing is crucial for predicting drug release from solid dosage forms.
- Understanding famotidine pharmacokinetics is essential for optimizing therapeutic efficacy.
- Automated analytical techniques enhance the efficiency and accuracy of drug analysis.
Purpose:
- To determine the dissolution rate of famotidine tablets using an automated system.
- To analyze the plasma concentration of famotidine over time in healthy volunteers.
- To characterize the pharmacokinetic profile of famotidine in humans.
Summary:
- Automated dissolution testing yielded a mean cumulative dissolution rate of 97.40% within 15 minutes for famotidine tablets.
- Pharmacokinetic analysis in six healthy volunteers after oral administration of 40 mg famotidine tablets revealed a one-compartment model.
- Key pharmacokinetic parameters calculated using a statistical moment algorithm included a half-life (T1/2) of 2.92 hours and an absolute bioavailability (Frel) of 118.8%.
Impact:
- The findings support the rapid release and good absorption of famotidine from the tested tablet formulation.
- This study provides valuable pharmacokinetic data for famotidine, aiding in clinical use and formulation development.
- The use of automated systems demonstrates efficient methodologies for drug dissolution and plasma analysis.