Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relation between systemic hypertension and pain perception.

D S Sheps1, E E Bragdon, T F Gray

  • 1University of North Carolina School of Medicine, Chapel Hill 27599-7075.

The American Journal of Cardiology
|November 16, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fit for Duty: Lessons Learned from Outpatient and Homebound Hematopoietic Cell Transplantation to Prepare Family Caregivers for Home-Based Care.

Transplantation and cellular therapy·2022
Same author

Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans.

Osteoarthritis and cartilage·2017
Same author

The impact of long-term moderate and heavy alcohol consumption on incident atherosclerosis among persons living with HIV.

Drug and alcohol dependence·2017
Same author

GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.

Journal of dental research·2017
Same author

Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies.

Journal of dental research·2016
Same author

COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain.

Journal of dental research·2015
Same journal

Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

The American journal of cardiology·2026
Same journal

ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

The American journal of cardiology·2026
Same journal

Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

The American journal of cardiology·2026
Same journal

Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

The American journal of cardiology·2026
Same journal

Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2026
Same journal

Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

The American journal of cardiology·2026
See all related articles

Hypertension may reduce pain perception. Studies show higher blood pressure correlates with increased pain threshold and tolerance, possibly involving beta-endorphin interactions.

Area of Science:

  • Cardiovascular Physiology
  • Pain Perception and Analgesia

Background:

  • Hypertension is a common cardiovascular condition.
  • The relationship between hypertension and pain perception is not fully understood.
  • Existing research suggests potential links between blood pressure regulation and pain modulation.

Purpose of the Study:

  • To investigate the hypothesis that hypertension diminishes pain perception in humans.
  • To evaluate the association between arterial blood pressure and thermal pain perception.
  • To explore the role of endogenous opioids in the hypertension-pain perception relationship.

Main Methods:

  • A study involving 20 men (10 hypertensive, 10 normotensive) to assess thermal pain threshold and tolerance.
  • Measurement of mean arterial pressure, plasma beta-endorphin levels.

Related Experiment Videos

  • Review of recent studies on hypertension and hypalgesia in animal models (rats, cats).

    • Main Results:

    • Mean arterial pressure was significantly related to thermal pain threshold (p=0.05) and tolerance (p=0.003).
    • Significant differences in baseline and posttest plasma beta-endorphin levels were observed between hypertensive and normotensive groups (p=0.02).
    • Animal studies indicated that elevated blood pressure and baroreceptor stimulation can suppress nociceptive responses.

    Conclusions:

    • Hypertension is associated with diminished pain perception, indicating an increased pain threshold.
    • An interaction between blood pressure regulation and endogenous opioid systems (beta-endorphin) likely mediates this effect.
    • Findings suggest a link between cardiovascular regulatory functions and pain control, potentially involving the baroreceptor system.