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Crohn's disease associated with cyclic neutropenia
R D Lamport1, S Katz, D Eskreis
1Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York.
The American Journal of Gastroenterology
|November 1, 1992
Summary
This case study details a rare instance of Crohn's disease co-occurring with cyclic neutropenia. The patient experienced no infections, and Crohn's disease appeared to worsen neutropenia.
Area of Science:
- Gastroenterology
- Hematology
- Immunology
Background:
- Neutropenia, a condition of low white blood cell count, is rarely associated with Crohn's disease independently of medication.
- Cyclic neutropenia is characterized by periodic drops in neutrophil count, increasing infection risk.
Observation:
- A unique case of Crohn's disease (CD) associated with cyclic neutropenia (CN) is presented, observed over a decade.
- The patient exhibited no recurrent bacterial infections or other typical sequelae of neutropenia.
- No direct correlation was found between white blood cell cycling and CD exacerbations, though CD appeared to exacerbate neutropenia.
Findings:
- Cyclic neutropenia patterns in this patient became evident only during disease quiescence and after medication withdrawal.
- The interplay between Crohn's disease activity and cyclic neutropenia was complex, with the former potentially worsening the latter.
Implications:
- This case highlights the importance of considering neutropenia in Crohn's disease patients, even without apparent drug association.
- Understanding this rare association may inform clinical and therapeutic decisions, including surgical interventions and the use of medications with neutropenic potential.
- Further research into white blood cell abnormalities in Crohn's disease is warranted.
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