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Luteal function in infertile patients with endometriosis
1Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan.
American Journal of Obstetrics and Gynecology
|July 1, 1992
Summary
Endometriosis in infertile women does not always indicate luteal phase defects. This study found no significant differences in progesterone levels between women with and without endometriosis during the luteal phase.
Area of Science:
- Reproductive Endocrinology
- Infertility Research
- Gynecologic Pathology
Background:
- Endometriosis is a common condition associated with infertility.
- Luteal phase defects (LPDs) are suspected in some infertile women with endometriosis.
- The relationship between endometriosis and LPDs requires further clarification.
Purpose of the Study:
- To investigate the prevalence of luteal phase defects in infertile patients diagnosed with endometriosis.
- To compare luteal function in infertile women with and without endometriosis.
Main Methods:
- Comparative study involving 24 infertile patients with endometriosis and 20 infertile controls without endometriosis.
- Daily serum hormone assays (luteinizing hormone, follicle-stimulating hormone, progesterone, estradiol) throughout the menstrual cycle.
- Histologic dating of endometrial biopsy specimens in a subset of patients with endometriosis.
Main Results:
- No statistically significant differences in mid-luteal and late-luteal phase progesterone levels were observed between the endometriosis and control groups.
- Histologic dating of endometrial biopsies revealed a luteal phase pattern in 7 out of 8 patients with endometriosis.
Conclusions:
- The findings suggest that luteal phase defects are not a universal characteristic of infertile patients with endometriosis.
- Further research may be needed to fully understand the complex interplay between endometriosis, infertility, and ovulatory function.