Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise-induced cellular alterations in the diaphragm.

S K Powers1, D Criswell, F K Lieu

  • 1Department of Exercise Science, University of Florida, Gainesville 32611.

The American Journal of Physiology
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Exploring mechanisms and contexts in a Peer Education Project to improve mental health literacy in schools in England: a qualitative realist evaluation.

Health education research·2023
Same author

Equal remission rates and reduced length of hospital stay with twice-daily repetitive transcranial magnetic stimulation (rTMS) for major depression - A large naturalistic retrospective cohort association study.

Progress in neuro-psychopharmacology & biological psychiatry·2023
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Interleukin-6 and total antioxidant capacity levels following <i>N</i>-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder.

Acta neuropsychiatrica·2020
Same author

Assessing uptake of the Harmonising Outcome Measures for Eczema (HOME) Core Outcome Set and recommended instruments.

The British journal of dermatology·2020

Endurance exercise training in aged rats improved diaphragm muscle oxidative capacity and capillary density. This was primarily achieved by reducing muscle fiber size, not increasing capillary-to-fiber ratio.

Area of Science:

  • Exercise physiology
  • Aging research
  • Skeletal muscle biology

Background:

  • Limited data exist on exercise training effects on diaphragm cellular oxidative capacity in senescent animals.
  • Aging is associated with declines in muscle function and oxidative capacity.
  • The diaphragm's role in respiration makes its adaptation to exercise crucial in aging.

Purpose of the Study:

  • To investigate the impact of a 10-week endurance training program on the cellular oxidative capacity, muscle cell cross-sectional area (CSA), and capillarity of the costal diaphragm in senescent rats.
  • To determine if endurance training can mitigate age-related declines in diaphragm muscle function.

Main Methods:

  • Twelve 24-month-old female Fischer 344 rats were divided into sedentary control and exercise training groups.

Related Experiment Videos

  • Trained rats underwent treadmill exercise (60 min/day, 5 days/wk) at 55-65% VO2max for 10 weeks.
  • Histological analysis identified capillaries and fiber types (ATPase), while computerized image analysis measured succinate dehydrogenase (SDH) activity and CSA.

    • Main Results:

    • Exercise training did not alter the capillary-to-fiber ratio in any fiber type.
    • Training significantly decreased CSA and increased capillary density (capillary number/CSA) in type I, IIa, and IIb fibers.
    • SDH activity increased significantly in type I and IIa fibers but not in type IIb fibers, with improvements largely attributed to reduced CSA.

    Conclusions:

    • Endurance training in senescent rats yields modest improvements in oxidative capacity and capillary density in type I and IIa costal diaphragm muscle fibers.
    • The observed benefits are primarily driven by a reduction in muscle fiber cross-sectional area.
    • These findings suggest that exercise can partially counteract age-related decrements in diaphragm muscle characteristics.