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Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis

K S Ginsburg1, M H Liang, L Newcomer

  • 1Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115.

Annals of Internal Medicine
|December 15, 1992
PubMed

Insights

Elevated anticardiolipin antibodies are a significant risk factor for venous thrombosis and pulmonary embolism in men. However, anticardiolipin antibodies do not appear to increase the risk of ischemic stroke in this population.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Anticardiolipin antibodies (aCL) are associated with an increased risk of thrombosis.
  • The role of aCL as a risk factor for specific thrombotic events like ischemic stroke and venous thromboembolism (VTE) requires further elucidation in healthy populations.

Purpose of the Study:

  • To investigate whether anticardiolipin antibodies are a risk factor for ischemic stroke and venous thrombosis in healthy adult men.

Main Methods:

  • A nested case-control study was conducted within the prospective Physicians' Health Study cohort.
  • Plasma samples from 22,071 male physicians were analyzed for IgG anticardiolipin antibodies using ELISA.
  • Conditional logistic regression was used to calculate relative risks for VTE and ischemic stroke based on aCL antibody titers.

Main Results:

  • Higher anticardiolipin antibody titers were observed in patients with deep venous thrombosis or pulmonary embolism compared to controls (P=0.01).
  • Individuals with aCL antibody titers above the 95th percentile had a 5.3-fold increased risk of developing deep venous thrombosis or pulmonary embolism (P=0.01).
  • No significant difference in aCL antibody titers was found between patients with ischemic stroke and controls, indicating no clear association.

Conclusions:

  • Anticardiolipin antibody levels above the 95th percentile are a significant risk factor for venous thromboembolism (deep venous thrombosis or pulmonary embolism) in healthy men.
  • Anticardiolipin antibodies are not identified as a risk factor for ischemic stroke in this cohort of healthy adult men.
Abstract

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