Related Experiment Videos
Activities of newer fluoroquinolones against Shigella sonnei
J F John1, L T Atkins, P A Maple
1Infectious Diseases Division, Medical University of South Carolina, Charleston 29425.
Abstract:
The activities of six fluoroquinolones were determined for 117 separate strains of Shigella sonnei. The order of increasing activity (MICs for 90% of strains tested) was enoxacin (0.25 micrograms/ml), temafloxacin (0.032 micrograms/ml), sparfloxacin (0.016 micrograms/ml), CI-960 (0.008 micrograms/ml), ciprofloxacin (0.008 micrograms/ml), and PD-131628-2 (0.008 micrograms/ml). These data, along with results of killing and mutational rate studies, showed that all six fluoroquinolones were highly inhibitory against S. sonnei and five fluoroquinolones were rapidly and persistently bactericidal.
Insights
Six fluoroquinolones demonstrated high antibacterial activity against Shigella sonnei strains. Five of these antibiotics were also found to be rapidly and persistently bactericidal, indicating their potential efficacy.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Shigella sonnei is a significant cause of bacterial dysentery.
- Fluoroquinolones are a class of synthetic broad-spectrum antibiotics.
- Understanding antibiotic activity against resistant pathogens is crucial for public health.
Purpose of the Study:
- To evaluate the in vitro activity of six fluoroquinolones against Shigella sonnei.
- To compare the potency and bactericidal effects of different fluoroquinolones.
Main Methods:
- Determined the minimum inhibitory concentrations (MICs) for 90% of strains tested (MIC90) for six fluoroquinolones against 117 Shigella sonnei isolates.
- Conducted killing studies and mutational rate analyses.
Main Results:
- All six fluoroquinolones exhibited high inhibitory activity against Shigella sonnei.
- The order of increasing activity was enoxacin, temafloxacin, sparfloxacin, CI-960, ciprofloxacin, and PD-131628-2.
- Five of the tested fluoroquinolones demonstrated rapid and persistent bactericidal activity.
Conclusions:
- The evaluated fluoroquinolones show significant potential for treating Shigella sonnei infections.
- Specific fluoroquinolones like CI-960, ciprofloxacin, and PD-131628-2 were the most potent in vitro.
- Further clinical investigation is warranted to confirm the therapeutic efficacy of these bactericidal agents.