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Primary carcinoid tumor of the urinary bladder
B F Walker1, A Someren, J C Kennedy
1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
Archives of Pathology & Laboratory Medicine
|November 1, 1992
Summary
This study reports a rare case of urinary bladder carcinoid tumor in a 62-year-old woman. The tumor exhibited characteristic neuroendocrine markers and an aneuploid DNA profile, indicating potential for malignancy.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Urinary bladder carcinoid tumors are rare neuroendocrine neoplasms.
- Diagnosis often relies on characteristic histological and immunohistochemical findings.
Observation:
- A 62-year-old woman presented with urinary frequency and microscopic hematuria.
- A 1.2 cm polypoid carcinoid tumor was identified in the urinary bladder.
Findings:
- Histopathology revealed residual carcinoid tumor with Brunn's nests, cystitis cystica, and cystitis glandularis.
- Tumor cells showed strong argyrophilia, weak argentaffinity, positive chromogranin and serotonin staining.
- Electron microscopy confirmed dense-core granules; flow cytometry showed an aneuploid population (DNA index 1.20).
Implications:
- This case highlights the importance of considering rare bladder tumors in patients with relevant symptoms.
- The findings contribute to the understanding of bladder carcinoid tumor biology and behavior.
- Aneuploidy may be a significant factor in the clinical management of such tumors.