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Biotransformation of the sympathomimetic tetraminol in vitro
K Drandarov1, E Kvasnicková, I M Hais
1Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czechoslovakia.
Archiv Der Pharmazie
|September 1, 1992
Abstract:
On incubation with the postmitochondrial fraction of the liver homogenate of rabbits, guinea-pigs, rats, and mice in the presence of NADPH and oxygen, the alpha-sympathomimetic trans-3-(2-hydroxyethylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-2-n aphthol (Tetraminol, 1) is preferentially O-demethylated in position 8, yielding metabolite 3. In male rats O-demethylation is stronger than in females.