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Skin reactions to diltiazem.
R A Wittal1, G O Fischer, K E Georgouras
1Dermatology Centre, Lidcombe Hospital, NSW.
The Australasian Journal of Dermatology
|January 1, 1992
Summary
Dermatologists observed various skin reactions to diltiazem, including erythema multiforme and urticarial vasculitis. This study details these reactions and reviews existing literature on diltiazem
Area of Science:
- Dermatology
- Pharmacology
Background:
- Diltiazem is a widely prescribed calcium channel blocker.
- Adverse skin reactions to medications are a significant clinical concern.
Observation:
- A survey of Australian dermatologists identified several skin reactions associated with diltiazem use.
- Observed reactions included erythema multiforme, subcorneal pustular dermatosis, photosensitive erythroderma, macular exanthem, allergic vasculitis, and urticarial vasculitis.
Findings:
- The study describes the clinical and histopathological features of these diltiazem-induced skin reactions.
- Photosensitive erythroderma and urticarial vasculitis appear to be previously unreported in the literature concerning diltiazem.
- This research expands the known spectrum of cutaneous adverse drug reactions to diltiazem.
Implications:
- Increased awareness among clinicians regarding the potential for diverse skin reactions to diltiazem.
- Highlights the need for vigilance in diagnosing and managing drug-induced dermatoses.
- Contributes to the pharmacovigilance of diltiazem, particularly concerning dermatological side effects.