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Statine based tripeptides as potent inhibitors of HIV-1 replication
J A Fehrentz1, B Chomier, E Bignon
1Sanofi Recherche, Montpellier, France.
Biochemical and Biophysical Research Communications
|October 30, 1992
Abstract:
Starting from highly potent HIV-1 protease pepstatine analog inhibitors, we have tried to find the minimum consensus sequence which is necessary to conserve anti-protease potency and antiviral activity. We describe here some statine based tripeptides which exhibit high affinity for the protease and are able to inhibit the reproductive cycle of HIV-1 in MT-4-infected cells.