Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Clonal origin of bladder cancer.

D Sidransky¹, P Frost, A Von Eschenbach

¹Department of Oncology, Johns Hopkins Oncology Center, Baltimore, MD 21231.

The New England Journal of Medicine

|March 12, 1992

Summary

Metachronous bladder tumors often arise from a single transformed cell, not independent field defects. Genetic analysis shows tumors from the same patient share early X-chromosome inactivation and chromosome 9q loss, indicating a common origin and subsequent independent genetic alterations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Erratum to "Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation" [Diagn. Interv. Imaging. 101 (2020) 35-44].

Diagnostic and interventional imaging·2020

Same author

Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features.

Diagnostic and interventional imaging·2020

Same author

Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis.

Diagnostic and interventional imaging·2019

Same author

Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation.

Diagnostic and interventional imaging·2019

Same author

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2019

Same author

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2015

Area of Science:

Oncology
Molecular Genetics
Urologic Pathology

Background:

Metachronous bladder tumors suggest a 'field defect' theory for independent cell transformation.
This study investigates the origin of multiple bladder tumors using molecular genetic techniques.

Purpose of the Study:

To test the 'field defect' hypothesis for metachronous bladder tumors.
To determine if multiple tumors in the same bladder originate from a single precursor cell.

Main Methods:

Analyzed X-chromosome inactivation patterns in 13 tumors from four patients.
Assessed allelic loss on autosomes, including chromosomes 9q, 17p, and 18q.

Main Results:

All tumors from individual patients shared the same X-chromosome inactivation pattern, unlike normal bladder cells.

Related Experiment Videos

Common loss of the same allele on chromosome 9q was observed in tumors from each patient.

Losses of chromosome 17p and 18q alleles, associated with advanced tumors, were not consistently found across different tumors from the same patient.

Conclusions:

Multiple bladder tumors can originate from a single transformed cell.
These tumors subsequently undergo independent genetic alterations as they progress.