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Simultaneous quantitative determination of calcium leucovorin and parabens in lyophilized ampoules by derivative
J Bertini1, A Cocchini, F Lamonaca
1Reparto Ricerche Analitiche A. Menarini Industrie Farmaceutiche Riunite S.R.L., Frenze.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1992
Abstract:
A simple and rapid procedure for quantitation of Calcium Leucovorin and parabens simultaneously in lyophilized ampoules formulation by "zero crossing" first-order derivative spectroscopy was developed. The ampoules content was dissolved in a mixture water/ethanol (50/50) and first-derivative spectra were recorded. The absolute values of the derivative at 312 nm for the determination of Calcium Leucovorin and between 244 and 246 nm for the determination of parabens were measured. The method is linear, quantitative and reproducible.