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Melatonin induced increase in gamma-interferon production by murine splenocytes
L L Colombo1, G J Chen, M C Lopez
1Department of Family and Community Medicine, Arizona Health Sciences Center, University of Arizona, Tucson 85724.
Immunology Letters
|July 1, 1992
Abstract:
Previously, we demonstrated that production of gamma-interferon (gamma-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased gamma-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).