Related Experiment Videos
Synthesis of optically pure C alpha-methyl-arginine
Z Tian1, P Edwards, R W Roeske
1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis.
International Journal of Peptide and Protein Research
|August 1, 1992
Abstract:
Optically pure L-(+)-C alpha-methyl-arginine and D-(-)-C alpha-methyl-arginine were synthesized. Experimental results indicated that DL-C alpha-methyl-arginine methyl ester could be resolved by trypsin, but workup posed a technical difficulty. Chemical resolution at the stage of DL-C alpha-methyl-ornithine, followed by selective guanidination using N,N'-di-Cbz-S-methylisothiourea and hydrogenolysis provided a effective and practical method for the synthesis of optically pure C alpha-methyl-arginine.