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Design and inhibitory properties of synthetic Bowman-Birk loops
D L Maeder1, M Sunde, D P Botes
1Department of Biochemistry, University of Cape Town, Rondebosch, Republic of South Africa.
International Journal of Peptide and Protein Research
|August 1, 1992
Abstract:
A cyclic tridecapeptide based on the sequence of an anti-tryptic loop of a Bowman-Birk inhibitor was synthesized, and demonstrated to be active as an inhibitor of trypsin. Molecular modeling of this sequence suggested an improved sequence which demonstrated an order of magnitude improvement in the inhibitory constant.