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Related Experiment Videos

Serotype B staphylococcal bacteriophage singly converting staphylokinase.

I Kondo, K Fujise

    Infection and Immunity
    |November 1, 1977
    PubMed
    Summary
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    A novel staphylococcal phage, Pphi-2, was identified, enabling the conversion of staphylokinase production. This discovery classifies staphylokinase into three types, including two mediated by phage lysogenic conversion.

    Area of Science:

    • Microbiology
    • Bacteriology

    Background:

    • Staphylokinase, a fibrinolysin produced by Staphylococcus aureus, plays a role in bacterial virulence.
    • Lysogenic conversion by bacteriophages is a known mechanism for altering bacterial traits.

    Purpose of the Study:

    • To isolate and characterize a new staphylococcal phage capable of converting staphylokinase production.
    • To differentiate the newly isolated phage from previously described staphylococcal phages.

    Main Methods:

    • Isolation and characterization of a novel staphylococcal phage (Pphi-2).
    • Comparative analysis of Pphi-2 with previously reported staphylococcal phages (Winkler et al.).

    Main Results:

    • Isolation of Pphi-2, a single-converting phage of serotype B, which converts staphylokinase production.

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  • Distinction of Pphi-2 from a serotype F phage (Winkler et al.) that converts both staphylokinase and beta-hemolysin.
  • Classification of staphylokinase into three types: chromosomal, Pphi-2-mediated conversion, and Winkler et al. phage-mediated conversion.

    • Conclusions:

    • Staphylokinase production can be mediated by lysogenic conversion through distinct bacteriophages.
    • The discovery of Pphi-2 expands the understanding of staphylokinase regulation and phage-host interactions in Staphylococcus aureus.