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Preimplantation diagnosis.

I Liebaers1, K Sermon, W Lissens

  • 1Centre for Medical Genetics, Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel, VUB), Belgium.

Human Reproduction (Oxford, England)
|June 1, 1992
PubMed
Summary
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Preimplantation diagnosis for sex determination in embryos is experimental. Blastomere biopsy is feasible, but analysis methods require improvement for clinical use.

Area of Science:

  • Reproductive medicine
  • Genetics

Background:

  • Preimplantation diagnosis (PID) for sex determination enables healthy births but remains experimental.
  • Micromanipulation of blastomeres from eight-cell embryos is a current biopsy method.

Purpose of the Study:

  • To evaluate the current status and future needs for preimplantation diagnosis for sex determination.

Main Methods:

  • Review of existing techniques for blastomere biopsy and analysis.
  • Discussion of the requirements for chromosomal, gene product, and DNA level analysis.

Main Results:

  • Blastomere removal via micromanipulation is currently acceptable.
  • Existing analytical methodologies for biopsied blastomeres need enhancement.

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Conclusions:

  • Further clinical application of PID for sex determination is contingent upon improved analytical techniques.
  • Ongoing research will yield more insights into early embryo development.