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Related Experiment Videos

Toxicity of 2-methyl-5,6-cyclopentapyrimidine (MCPP).

G L Kennedy1

  • 1E. I. Du Pont de Nemours and Co., Inc., Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714.

Journal of Applied Toxicology : JAT
|October 11, 1992
PubMed
Summary

2-Methyl-5,6-cyclopentapyrimidine (MCPP) is a potent acute toxin. Oral and inhalation studies in rats revealed moderate toxicity, with significant effects including convulsions and liver injury at specific doses.

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Area of Science:

  • Toxicology
  • Chemical Safety
  • Polymer By-products

Background:

  • 2-Methyl-5,6-cyclopentapyrimidine (MCPP) is a by-product of experimental polymer synthesis.
  • This compound possesses a strong odor and is a white dusty solid.

Purpose of the Study:

  • To determine the acute toxicity of MCPP via oral and inhalation routes in rats.
  • To evaluate the effects of repeated MCPP inhalation exposure.
  • To assess the mutagenic potential of MCPP.

Main Methods:

  • Acute oral toxicity testing (LD50 determination) in rats.
  • Acute inhalation toxicity testing (LC50 determination) in rats.
  • Repeated inhalation exposure studies (9 daily exposures).
  • Mutagenicity testing using Salmonella.

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Main Results:

  • MCPP is moderately toxic orally (LD50 = 90 mg/kg) and highly toxic via inhalation (LC50 ≈ 9 ppm).
  • Observed effects include convulsions, salivation, hyperactivity, and liver injury at specific doses.
  • Histological findings indicated hyperemia; no liver or CNS damage was observed.
  • Repeated inhalation of 2 ppm MCPP showed no toxic response, and no mutagenic activity was detected.

Conclusions:

  • MCPP is a potent acute toxin, particularly via inhalation.
  • Further risk assessment is warranted due to its acute toxicity profile.
  • No mutagenic effects were observed in the tested conditions.