[Mathematical model of transient long-term adaptation processes of the heart]

A mathematical model of the heart's long-term adaptation to changing load is described. The model is based on the long-term adaptation concept which assumes the phosphorylation potential changing in the heart muscle cells with the load to control the genetic apparatus activity and thus determine structural alterations ensuring adaptation. The computerized model reproduces the transient process in four major types of the heart's long-term adaptation, i.e. in a compensatory hypertrophy development and hypertrophy regression, as well as in the training and detraining states formation. The simulation results are in agreement with the available data and predict the phenomena that are not as yet substantiated by experiments.