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The relationship between first-phase insulin secretion and glucose metabolism
E I Widén1, J G Eriksson, A V Ekstrand
1Fourth Department of Medicine, Helsinki University Hospital, Finland.
Acta Endocrinologica
|October 1, 1992
Summary
Restoring first-phase insulin secretion did not improve glucose uptake in insulin-resistant individuals. This suggests that impaired first-phase insulin secretion is not the primary cause of glucose metabolism issues in these subjects.
Area of Science:
- Metabolic Research
- Endocrinology
- Human Physiology
Background:
- Cross-sectional studies suggest a link between impaired first-phase insulin secretion and glucose metabolism disorders.
- First-phase insulin secretion is correlated with glucose disposal during hyperglycemic clamps.
Purpose of the Study:
- To investigate if restoring first-phase insulin secretion improves peripheral glucose uptake in insulin-resistant subjects.
- To determine the role of first-phase insulin secretion in glucose utilization.
Main Methods:
- Utilized hyperglycemic glucose clamp technique with [3-3H]glucose infusion.
- Measured substrate oxidation rates and hepatic glucose production via indirect calorimetry.
- Restored first-phase insulin secretion using an intravenous insulin bolus.
Main Results:
- Insulin-resistant subjects with impaired first-phase insulin secretion showed reduced total glucose uptake compared to controls.
- Restoration of first-phase insulin secretion did not significantly alter glucose uptake.
- No differences in oxidative or non-oxidative glucose metabolism were observed after restoring first-phase insulin secretion.
Conclusions:
- Impaired first-phase insulin secretion may not be the direct cause of impaired glucose uptake in insulin resistance.
- The study challenges the direct pathogenetic link between absent first-phase insulin secretion and impaired glucose metabolism.