Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of atherosclerosis.

A V Chobanian1

  • 1Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts.

The American Journal of Cardiology
|November 27, 1992
PubMed
Summary

New research reveals oxidized low-density lipoprotein (LDL) and lipoprotein(a) contribute to atherosclerosis. Combined hypercholesterolemia and hypertension significantly accelerate plaque formation through complex mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Control of hypertension--an important national priority.

The New England journal of medicine·2001
Same author

National Heart, Lung, and Blood Institute Workshop on Sodium and Blood Pressure : a critical review of current scientific evidence.

Hypertension (Dallas, Tex. : 1979)·2000
Same author

Adventitia as a source of inducible nitric oxide synthase in the rat aorta.

American journal of hypertension·1999
Same author

Comparison of the effects of AT1 receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis.

American journal of hypertension·1999
Same author

Alpha1-adrenergic plus angiotensin receptor blockade reduces atherosclerosis in apolipoprotein E-deficient mice.

Hypertension (Dallas, Tex. : 1979)·1998
Same author

Effect of nitric oxide on DNA replication induced by angiotensin II in rat cardiac fibroblasts.

Hypertension (Dallas, Tex. : 1979)·1997

Area of Science:

  • Cardiovascular Biology
  • Atherosclerosis Research

Background:

  • Atherosclerotic plaque formation involves complex biological processes.
  • Oxidized low-density lipoprotein (LDL) and lipoprotein(a) are implicated in atherogenesis.
  • Endothelial dysfunction and smooth muscle cell proliferation are early arterial injury events.

Purpose of the Study:

  • To elucidate fundamental processes in atherosclerotic plaque formation.
  • To investigate the atherogenic potential of modified LDL subclasses.
  • To understand the synergistic effects of hypertension and hypercholesterolemia on atherogenesis.

Main Methods:

  • Review of recent experimental evidence on lipoprotein metabolism and arterial injury.
  • Analysis of factors influencing endothelial function and smooth muscle cell responses.
  • Examination of the combined impact of hypertension and hypercholesterolemia.

Main Results:

  • Oxidized LDL is taken up more readily by macrophages, increasing its atherogenicity.
  • Lipoprotein(a) may promote platelet aggregation and thrombus formation.
  • Hypertension and hypercholesterolemia exhibit a synergistic effect on promoting atherosclerosis.

Conclusions:

  • Modified LDL subclasses and lipoprotein(a) play significant roles in atherosclerosis development.
  • Early arterial changes are linked to endothelial dysfunction and smooth muscle cell proliferation.
  • The combined effect of hypertension and hypercholesterolemia on atherogenesis warrants further investigation.

Related Experiment Videos