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Abuse of monoamine oxidase inhibitors
1Langley Porter Psychiatric Institute, University of California, San Francisco 94143.
The American Journal of Drug and Alcohol Abuse
|January 1, 1992
Abstract:
Monoamine oxidase inhibitors, like other antidepressants, generally are considered free of risk for abuse. There is, however, some evidence that MAOIs possess dependence and abuse potential for some patients. We will review the available literature and describe three current cases. Recommendations for treatment are discussed briefly.
Insights
Monoamine oxidase inhibitors (MAOIs), often seen as safe antidepressants, may carry risks for abuse and dependence in some individuals. This review examines the literature and presents cases to inform treatment strategies for MAOI abuse.
Area of Science:
- Psychiatry
- Pharmacology
- Neuroscience
Background:
- Monoamine oxidase inhibitors (MAOIs) are a class of antidepressants.
- They are generally perceived as having a low potential for abuse compared to other antidepressants.
- However, emerging evidence suggests a potential for dependence and abuse in certain patient populations.
Observation:
- This study reviews existing literature on MAOI abuse and dependence.
- Three clinical cases illustrating MAOI abuse or dependence are presented.
- The cases highlight the clinical manifestations and challenges associated with MAOI misuse.
Findings:
- The review supports the hypothesis that MAOIs possess a potential for abuse and dependence.
- Clinical data indicates that specific patient factors may predispose individuals to MAOI misuse.
- The presented cases demonstrate the varied presentations of MAOI-related substance use disorders.
Implications:
- Clinicians should be aware of the potential for MAOI abuse and dependence.
- Screening for substance use disorders may be warranted in patients prescribed MAOIs.
- Further research is needed to understand the mechanisms and prevalence of MAOI abuse, informing safer prescribing practices.