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Gastric acid secretion in HIV-1 infection
R T Shaffer1, L J LaHatte, J W Kelly
1Department of Medicine, Brooke Army Medical Center, San Antonio, Texas.
The American Journal of Gastroenterology
|December 1, 1992
Summary
This study found no significant differences in gastric acid secretion between HIV-infected males and controls. The stage of human immunodeficiency virus (HIV) infection did not affect gastric acid output in non-AIDS patients.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Immunology
Background:
- Reduced gastric acid output is a concern in Acquired Immunodeficiency Syndrome (AIDS) patients, potentially affecting oral antifungal absorption.
- The factors influencing gastric acid reduction in AIDS patients remain unclear.
- This study focuses on non-AIDS Human Immunodeficiency Virus type 1 (HIV-1) infected individuals.
Purpose of the Study:
- To investigate gastric acid output in relation to the clinical stage of non-AIDS HIV-1 infection.
- To determine if HIV infection impacts basal and stimulated gastric acid secretion.
Main Methods:
- Compared gastric acid output (basal, maximal, peak) and fasting serum gastrin levels.
- Included nine healthy controls and 26 male HIV-1 infected subjects across different disease stages.
- Statistical analysis was performed to assess differences and relationships.
Main Results:
- No statistically significant differences were observed in basal acid output, maximal acid output, peak acid output, or fasting serum gastrin between HIV-infected subjects and controls.
- No correlation was found between the stage of HIV infection and gastric acid secretion parameters.
Conclusions:
- Basal and maximally stimulated gastric acid secretion are not impaired in non-AIDS HIV-1-infected males.
- The clinical stage of non-AIDS HIV-1 infection does not influence gastric acid secretion.