Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ventricular repolarization].

C Funck-Brentano1

  • 1Unité de pharmacologie clinique, hôpital Saint-Antoine, Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Ventricular repolarisation, measured by the QT interval, is crucial for cardiac health. Heart rate significantly impacts repolarisation duration, affecting drug development and cardiac pathology risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytochrome P-450-mediated herb and food-drug interactions can be identified in cancer patients through patient self-reporting with a tablet application: results of a prospective observational study.

ESMO open·2022
Same author

Monitoring of plasma concentrations of dabrafenib and trametinib in advanced BRAFV600<sup>mut</sup> melanoma patients.

Annales de dermatologie et de venereologie·2021
Same author

Androgenic effects on ventricular repolarization: A translational study from the international pharmacovigilance database to iPSC-cardiomyocytes.

Annales d'endocrinologie·2020
Same author

Clinical pharmacology of anti-angiogenic drugs in oncology.

Critical reviews in oncology/hematology·2017
Same author

Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Reply to the letter to the editor 'Plasma vemurafenib concentrations in advanced BRAFV600mut melanoma patients: impact on tumor response and tolerance' by Funck-Brentano et al.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same journal

Radiokymographic study of the kinetics of the middle arc and the hils in the normal subject.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

A medication for angina pectoris and pre-fibrillatory conditions; 1262 F; six years of clinical experience; action mechanism.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Circulatory changes following the injection of hypertonic saline solutions; application to the study of angina pectoris.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Alterations in coronary circulation during aortic insufficiency in young subjects.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Cardio-esophageal auscultation.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Hypertensive accidents following the injection of acetylcholine.

Archives des maladies du coeur et des vaisseaux·2010
See all related articles

Area of Science:

  • Cardiology
  • Electrophysiology

Context:

  • Ventricular repolarisation duration is assessed via the electrocardiogram's QT interval.
  • Manual QT interval measurement faces precision challenges.
  • Automatic systems offer improved accuracy for QT interval assessment.

Purpose:

  • To highlight the physiological variations affecting ventricular repolarisation.
  • To emphasize the complex influence of heart rate on repolarisation.
  • To discuss the implications of QT interval changes in pharmacology and pathology.

Summary:

  • Ventricular repolarisation, assessed by the QT interval, is vital for cardiac excitability.
  • Heart rate is a primary factor influencing repolarisation duration.
  • Accurate QT interval measurement is critical for interpreting drug effects and cardiac conditions.

Related Experiment Videos

Impact:

  • Prolonged QT intervals and poor heart rate adaptation increase torsades de pointe risk.
  • Understanding rate-dependent drug effects on repolarisation is essential for new drug development.
  • QT interval prolongation is linked to adverse outcomes post-myocardial infarction.