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Related Experiment Videos

Fasting in the rat does not induce hyperfibrinogenaemia.

I S Watts1, D G White, J Coates

  • 1Department of Cardiovascular and Respiratory Pharmacology, Glaxo Group Research Ltd, Hertfordshire, U.K.

Biochemical Pharmacology
|November 17, 1992
PubMed
Summary
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Fasting rats for 24-48 hours increased non-esterified fatty acids in plasma but did not affect fibrinogen levels. This study investigates the relationship between fasting, fatty acids, and fibrinogen in rats.

Area of Science:

  • Biochemistry
  • Physiology
  • Animal Studies

Background:

  • Fasting is known to alter metabolic parameters.
  • Non-esterified fatty acids (NEFAs) are key indicators of lipolysis during fasting.
  • The impact of fasting-induced metabolic changes on plasma fibrinogen is not fully understood.

Purpose of the Study:

  • To investigate the effect of short-term fasting on plasma fibrinogen concentration in rats.
  • To examine the correlation between fasting-induced changes in non-esterified fatty acids and fibrinogen levels.

Main Methods:

  • Rats were subjected to fasting for a duration of 24 to 48 hours.
  • Plasma concentrations of non-esterified fatty acids and fibrinogen were measured.
  • Comparative analysis of plasma components between fasted and control groups.

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Main Results:

  • Fasting for 24-48 hours resulted in a significant 4-5 fold increase in plasma non-esterified fatty acids.
  • No significant increase in plasma fibrinogen concentration was observed in fasted rats compared to controls.
  • The elevation in non-esterified fatty acids did not correlate with changes in fibrinogen levels.

Conclusions:

  • Short-term fasting in rats elevates plasma non-esterified fatty acids but does not increase plasma fibrinogen.
  • The metabolic response to fasting, characterized by increased lipolysis, does not directly stimulate fibrinogen production in this model.
  • Further research is needed to elucidate the complex interplay between fasting, fatty acid metabolism, and coagulation factors.