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Dolichol: function, metabolism, and accumulation in human tissues.

K K Carroll1, N Guthrie, K Ravi

  • 1Department of Biochemistry, University of Western Ontario, London, Canada.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|June 1, 1992
PubMed
Summary

Dolichol, essential for glycoprotein synthesis, accumulates with age and in lipid diseases. Its buildup, along with dolichyl phosphate and cholesterol, can negatively impact tissues despite their metabolic roles.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Lipid Metabolism

Background:

  • Dolichol, a series of polyisoprenoid alcohols, is crucial for N-linked glycoprotein biosynthesis.
  • Dolichol synthesis shares pathways with cholesterol biosynthesis and can be similarly inhibited.
  • Dolichol is metabolized slowly, leading to tissue accumulation over time.

Purpose of the Study:

  • To review the metabolic roles and accumulation patterns of dolichol and its derivatives.
  • To highlight the potential adverse effects of dolichol accumulation in aging and disease.

Main Methods:

  • Literature review of dolichol biochemistry and metabolism.
  • Analysis of dolichol accumulation in aging and lipid storage diseases.
  • Comparison of dolichol accumulation with cholesterol and dolichyl phosphate.

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Main Results:

  • Dolichol, dolichyl phosphate, and cholesterol accumulate in tissues during aging.
  • Dolichol accumulation is more pronounced than cholesterol or dolichyl phosphate during aging.
  • Significant dolichol accumulation occurs in specific lipid storage diseases.

Conclusions:

  • Despite essential functions, excessive dolichol accumulation can be detrimental.
  • Understanding dolichol metabolism is key to addressing age-related and disease-related lipid imbalances.