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Iodixanol--a new nonionic dimer--in aortofemoral angiography
U Albrechtsson1, H Lárusdóttir, L Norgren
1Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Acta Radiologica (Stockholm, Sweden : 1987)
|November 1, 1992
Summary
Iodixanol, a new contrast agent, proved safe and well-tolerated in aortofemoral angiography. Both tested concentrations (270 and 320 mg I/ml) showed similar mild side effects and effective radiographic outcomes.
Area of Science:
- Radiology
- Medical Imaging
- Cardiovascular Interventions
Background:
- Aortofemoral angiography requires effective and safe contrast media.
- Iodixanol is a novel nonionic dimer contrast agent designed for improved safety and isotonicity.
Purpose of the Study:
- To evaluate the safety, tolerability, and radiographic efficacy of iodixanol.
- To compare two different concentrations of iodixanol (270 mg I/ml and 320 mg I/ml) in patients undergoing aortofemoral angiography.
Main Methods:
- A prospective trial involving 26 patients undergoing aortofemoral angiography.
- Patients received either 270 mg I/ml or 320 mg I/ml iodixanol.
- Assessment included patient-reported discomfort, adverse events, serum chemistry, and diagnostic image quality.
Main Results:
- No clinically significant changes in serum chemistry parameters were observed.
- Adverse events were mild and transient, primarily a sensation of warmth.
- Radiographic efficacy was comparable between the 270 mg I/ml and 320 mg I/ml concentrations.
Conclusions:
- Iodixanol is a safe and well-tolerated contrast medium for adult femoral angiography.
- Both tested concentrations demonstrate similar safety profiles and diagnostic effectiveness.
- Further research may explore iodixanol in broader angiographic applications.