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CD4+ T cells in atherosclerosis

Xinghua Zhou1

  • 1Center for Molecular Medicine L8:03 and Department of Medicine, Karolinska Hospital, Karolinska Institutet, 17176, Stockholm, Sweden. xinghua.zhou@cmm.ki.se

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 23, 2003
PubMed

Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density lipoproteins from lesions suggest that a cell-mediated immune reaction is taking place in atherosclerosis. This review provides an overview of our current understanding of the roles of CD4(+) T cell subpopulations in atherosclerosis.

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