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Isolation and Transplantation of Different Aged Murine Thymic Grafts.
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Dominant transplantation tolerance. Opinion

Luis Graca1, Alain Le Moine, Stephen P Cobbold

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. luis.graca@pathology.oxford.ac.uk

Current Opinion in Immunology
|September 23, 2003
PubMed

Long-term allograft survival in the absence of continuous immunosuppression can be induced following a short treatment of nondepleting antibodies, such as those that target CD4 or CD154 (CD40 ligand). It is now established that this may involve dominant tolerance mechanisms that are maintained by CD4+ regulatory T cells present within the lymphoid tissue and the tolerated graft. The phenotype of these cells, their relationship to CD4+CD25+ T cells, and the mechanism of action are still controversial.

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