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Related Experiment Videos

On bone adaptation due to venous stasis.

Liyun Wang1, Susannah P Fritton, Sheldon Weinbaum

  • 1Department of Orthopaedics, The Mount Sinai School of Medicine, New York, NY 10029, USA .

Journal of Biomechanics
|September 23, 2003
PubMed
Summary

Interstitial fluid flow from blood circulation is unlikely to cause bone formation during venous stasis. However, increased mean interstitial fluid pressure in venous stasis may play a role in periosteal bone formation.

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Area of Science:

  • Biomechanics
  • Skeletal Biology
  • Fluid Dynamics

Background:

  • Periosteal bone formation is observed in conditions of compromised venous return (venous stasis).
  • Increased interstitial fluid flow, driven by elevated intramedullary pressure, has been hypothesized to cause this periosteal response.

Purpose of the Study:

  • To investigate the shear stresses on bone cell processes caused by interstitial fluid flow driven by blood circulation.
  • To determine if interstitial fluid flow can account for periosteal bone formation in venous stasis.

Main Methods:

  • A poroelastic model was used to simulate interstitial fluid flow in an osteon.
  • The model incorporated pulsatile extravascular pressure from cardiac and skeletal muscle contractions, as well as cyclic mechanical loading.

Related Experiment Videos

  • Shear stresses on osteocyte cell processes were calculated under normal and venous stasis conditions.

    • Main Results:

    • Under normal conditions, pulsatile pressures induced peak shear stresses two orders of magnitude lower than physiological mechanical loading.
    • In venous stasis, peak shear stress was reduced due to decreased pulsatile component of intramedullary pressure.
    • Mean interstitial fluid pressure increased significantly in venous stasis.

    Conclusions:

    • Interstitial fluid flow is unlikely to be the primary driver of periosteal bone formation in venous stasis.
    • Elevated mean interstitial fluid pressure in venous stasis may contribute to periosteal bone formation by pressurizing the periosteum.