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Updated: Aug 31, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Symptomatic migraine and sensitization of trigeminal nociception associated with contralateral pontine cavernoma
Zaza Katsarava1, Thomas Egelhof, Holger Kaube
1Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Abstract:
A 38-year-old woman is described with symptomatic strictly right-sided migraine associated with a pontine cavernoma affecting the contralateral (left) nucleus raphe magnus. A persistent facilitation of the right-sided trigeminal nociception was detected interictally using the 'nociception specific' blink reflex, which was more pronounced during the acute attack. This case shows for the first time, an impairment of the anti-nociceptive brainstem nuclei and the facilitation of the trigeminal nociception in the same subject, thus providing further evidence for the key role of the brainstem raphe nuclei in the pathophysiology of migraine.
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