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Cell adhesion molecules in Hodgkin's disease.

E Paietta1

  • 1Department of Oncology, Montefiore and Albert Einstein Cancer Center, Bronx, New York.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|September 1, 1992
PubMed
Summary

Hodgkin

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Area of Science:

  • Immunology and Cell Biology

Background:

  • Hodgkin's cells exhibit lymphocyte-binding capabilities in vivo and in vitro.
  • This interaction suggests the presence of cell adhesion molecules on Hodgkin's cells.

Purpose of the Study:

  • To investigate the expression of adhesion molecules on cultured Hodgkin's cells.
  • To characterize the adhesive properties of Hodgkin's cells.

Main Methods:

  • Cell culture of Hodgkin's cells.
  • Analysis of cell surface adhesion molecule expression.

Main Results:

  • Cultured Hodgkin's cells demonstrate a high number of adhesive sites.
  • These sites include molecules from diverse adhesion molecule families.

Conclusions:

  • Hodgkin's cells possess significant adhesive properties mediated by various adhesion molecules.
  • The expression of these molecules likely contributes to lymphocyte binding observed in Hodgkin's lymphoma.

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